ONCO.IO

ONCO.IO is an integrative resource for microrna and transcription factors analysis in cancer.

Network analysis tools Build network by filter

Find rsID by SNP chr/position

Database is updated every day
last update: MIR489=>PAX3, 2018-05-27 00:54:52 by rhizoman1

ONCO.IO statistics

Total number of interactions:
14286

binding of miRNA:
5394

transcription regulation:
4140

drug interactions:
454

chemo/drugresistance:
198


metabolic reactions:
8231

TF => ncRNA reactions:
653

drug => gene/miR reactions:
454


Path. processes associations:
11887

Diseases associations:
7879

Pubmeds:
16283

Express.levels associations:
3183

Prognosis associations:
1332

Diagnosis associations:
52

Biomarker localization:
3562

Cell lines associations:
15618

Tumor stage associations:
54

Methods associations:
41129

Cell Localization:
407

number of new added interactions:
for last week:
44
(
-73
)
for last 2 weeks:
161

for last month:
256 (
-70
)

for last two month:
582

graph view


top annotators of last month:
rhizoman1:
256
(
-70
)

ONCO.IO is an integrated knowledge database and network analysis tool for exploring complex gene regulatory networks involved in cancer.

ONCO.IO database content is based on the manually curated annotation of experimentally verified molecular interactions described in the literature and includes microRNAs, lncRNAs, mRNAs, signaling proteins and transcription factors interactions.

Key features:



Search term and build network:


Processes

Pathogenic process (PP) - molecular, cellular or tissue malfunction determining initiation, development and outcome of disease. Full list of PP is here
Interactions (or edges) are associated with pathogenic process and can influence as positively and negatively on the process.

Processes:

Diseases

Diseases:

Genes and ncRNAs

Symbol:



News:

Video on the work of ONCO.IO 15 May 2018 14:05:59 by Sasha Fokin

Next week we dedicate memory Jacques Derrida who died of pancreatic cancer! 29 April 2018 00:30:52 by rhizoman1

Pancreatic cancer is a most dangerous cancer in the world! We will annotate new interactions to improve our understanding this dangerous cancer! Please contact with us info@onco.io

Orphan microrna in our DB! 27 April 2018 22:14:28 by rhizoman1
Unfortunately, we have in our DB micrornas without interactions. If it possible, we will fix these flaws! If you find these flaws, immediately report on info@onco.io! We immediately add appropriate interactions! We are waiting your suggestions!

Much more and more interactions! 30 January 2018 01:22:02 by rhizoman1
After a period of dormancy we are working hard!

Drug resistance, Apoptosis and more! 16 December 2017 17:07:26 by rhizoman1
Next week we will annotate apoptosis interactome. It is known, that apoptosis is key process which determines efficacy of anti-cancer therapy. One of the cancer hallmark is resisting cell death. Understanding how can make rewiring in apoptotic network in cancer cells plays crucial role for enhanced cancer drug sensitivity!

E3 ubiquitin ligases and their regulatory interactions in cancer 03 December 2017 18:17:07 by rhizoman1
In the next week we will annotate E3 ubiquitin ligase interactome! As always, it will be regulatory interactions between mIRs/TFs and E3 ubiquitin ligase mRNAs/genes. And it will also include array of E3 ligase substrates. E3 ubiquitin ligases play an essential role in the regulation of many biologic processes, especially in cancer development.

How to find rs ID by SNP chromosome and position 01 December 2017 12:46:28 by Sasha Fokin
We made fast web tool, which find rs ID by SNP chromosome and position. This tool work with last data build -- snp150, and with two assembly versions: HG19 / GRCh37 (234,756,361 SNPs) and HG38 / GRCh38 (335,322,261 SNPs).


Blog

Last saved networks:

fasdfsda [25 May 2018 12:41:57 by guest -- 117.16.196.132 / REPUBLIC OF KOREA]
31 + 94 [20 May 2018 13:13:02 by guest -- 217.146.218.171 / ISLAMIC REPUBLIC OF IRAN]
c [17 May 2018 18:33:31 by guest -- 14.139.160.243 / INDIA]
hsa-mirlet-7a1 hsa-mir4511 test.. [16 May 2018 15:54:48 by guest -- 87.245.153.236 / RUSSIAN FEDERATION]
from mir301a to sufu [14 May 2018 16:00:21 by guest -- 62.219.54.250 / ISRAEL]
12 [06 May 2018 20:49:42 by guest -- 72.133.226.105 / UNITED STATES]
12 [06 May 2018 19:32:31 by guest -- 72.133.226.105 / UNITED STATES]
12 [06 May 2018 19:32:03 by guest -- 72.133.226.105 / UNITED STATES]
network_1525544327 [05 May 2018 23:18:50 by guest -- 46.224.171.137 / unknown]
ALL-MDR [05 May 2018 20:25:00 by guest -- 46.224.171.137 / unknown]
splash [04 May 2018 13:28:57 by Sasha Fokin -- 50.7.184.98 / unknown]
whatever test network [04 May 2018 12:54:20 by guest -- 50.7.184.98 / unknown]
HR [27 April 2018 18:00:12 by guest -- 200.17.203.99 / BRAZIL]
hcc-ev [26 April 2018 23:42:03 by guest -- 200.17.203.99 / BRAZIL]
[21 April 2018 15:47:07 by guest -- 54.165.59.7 / UNITED STATES]
metabolomic regulomics test [18 April 2018 21:40:56 by guest -- 87.245.153.236 / RUSSIAN FEDERATION]
FZD transfac test [18 April 2018 13:47:06 by guest -- 213.87.134.61 / RUSSIAN FEDERATION]
cancer predisposition genes_v1 [13 April 2018 02:27:11 by guest -- 79.111.161.11 / RUSSIAN FEDERATION]
WNT_upstream regulation_v1 [02 April 2018 17:32:11 by guest -- 62.148.8.173 / RUSSIAN FEDERATION]
WNT_upstream regulation_v1 [01 April 2018 15:49:39 by guest -- 176.193.190.218 / unknown]
WNT_p4_core [31 March 2018 17:34:57 by guest -- 176.193.190.218 / unknown]
WNT_p3_core [29 March 2018 11:46:58 by guest -- 176.193.142.250 / unknown]
WNT_p3_core [28 March 2018 16:21:01 by guest -- 62.148.8.173 / RUSSIAN FEDERATION]
WNT signaling cascade old test 3 (27.03.2018) [28 March 2018 13:05:37 by guest -- 87.245.153.236 / RUSSIAN FEDERATION]
cAMP-CREB pathway_v1 [28 March 2018 12:14:50 by rhizoman1 -- 176.193.169.155 / unknown]
WNT_p2_core [28 March 2018 11:41:41 by guest -- 176.193.169.155 / unknown]
WNT signaling cascade old test 3 (27.03.2018) [27 March 2018 19:55:18 by guest -- 87.245.153.236 / RUSSIAN FEDERATION]
WNT_p1_core [27 March 2018 19:16:21 by rhizoman1 -- 176.193.169.155 / unknown]
WNT signaling cascade old test 2 (27.03.2018) [27 March 2018 16:06:52 by guest -- 87.245.153.236 / RUSSIAN FEDERATION]
metabolic receptors test 3 [26 March 2018 20:32:01 by guest -- 87.245.153.236 / RUSSIAN FEDERATION]
metabolic receptors test 3 [26 March 2018 20:30:21 by guest -- 87.245.153.236 / RUSSIAN FEDERATION]
EMT sinnaling pathway with microRNA and lncRNA [26 March 2018 18:18:06 by guest -- 87.245.153.236 / RUSSIAN FEDERATION]
metabolites regulatome test [26 March 2018 18:02:55 by guest -- 87.245.153.236 / RUSSIAN FEDERATION]
levels test [26 March 2018 15:58:17 by Sasha Fokin -- 87.245.153.236 / RUSSIAN FEDERATION]
levels test [26 March 2018 15:40:44 by guest -- 87.245.153.236 / RUSSIAN FEDERATION]
receptors? [23 March 2018 17:09:46 by guest -- 87.245.153.236 / RUSSIAN FEDERATION]
metabolites PTG receptors test [23 March 2018 13:20:53 by Sasha Fokin -- 87.245.153.236 / RUSSIAN FEDERATION]
met1 test [23 March 2018 11:25:20 by guest -- 87.245.153.236 / RUSSIAN FEDERATION]
only lncRNAs and microRNAs network [20 March 2018 22:31:03 by guest -- 46.188.122.70 / unknown]
lncRNA and microRNA interactions network [20 March 2018 22:25:32 by guest -- 46.188.122.70 / unknown]

All saved networks




Coming soon:


Metabolites

Pubmeds

Drugs

Interactions

Mutations

Educational game