miRs in prostate cancer: comlex regulatory connections with cancer hallmarks 18 January 2019 23:53:17 by Rhizoman1
Next week we will annotate regulatory interactions in prostate cancer. Prostate cancer (PCa) is considered the most prevalent malignancy and the second major cause of cancer-related death in males from Western countries. Androgen deprivation therapy (ADT) is the primary treatment option for male patients with advanced symptomatic PCa. Castration-resistant prostate cancer (CRPC) refers to the continuous progression of PCa following ADT. We will focus on the role of non-coding RNAs and transcription factors in prostate cancer development and progression.
The program of reduce the critical dependence of Russian science on foreign genetic and biological databases. 26 December 2018 16:10:04 by Sasha Fokin
"The Ministry of Education and Science proposes to allocate 220.5 billion rubles. on the development of genetic technologies in the framework of the federal scientific and technical program for the years 2019-2027.
This is stated in the draft government decree on the approval of the program, published on Friday on the federal portal of draft regulations. The implementation of the program is designed to "reduce the critical dependence of Russian science on foreign genetic and biological data bases, foreign specialized software and devices, the programs passport says. In Russia, bioinformatics and genetic databases, basic reagents and software products and equipment prototypes should be created."
The leading scientific organization will be the Kurchatov Institute. The ONCO.IO is made entirely by our forces and means without the help of any other structures and organizations. This is a completely independent product. For all inhabitants of the planet Earth, we provide equal access to ONCO.IO and his services.
Immune response interactome! 06 October 2018 01:24:29 by Rhizoman1
T-cell-DC, signaling and regulatory pathways that develop immune response. Co-regulatory and repressor molecules. Receptors, signaling molecules, transcription factors as are drivers of anti-cancer immunity. Next week we will annotate immunoregulatory interactome! This is dedicated to the Nobel prize in Physiology or Medicine 2018!
NRF2 and TRIM proteins , where is conection? 17 September 2018 00:15:16 by Rhizoman1
In addition to NRF2 interactome we will integrate TRIM proteins interactome! TRIM (Tripartite motif (TRIM) proteins) are a versatile family of ubiquitin E3 ligases
involved in a multitude of cellular processes. Oxidative stress and aniviral response)
We will annotate autophagy interactome! 04 August 2018 18:12:02 by Rhizoman1
Autophagy is an evolutionarily conserved catabolic
process that has an essential role in cellular homeostasis. Autophagy decline with age in most tissues. And aging could be caused by declined autophagy levels.
Transcription factors interactions in specific cancer context 09 June 2018 23:08:34 by Rhizoman1
Next week we will annotate TF-->target interactions that are associated with cancer! Many of these interactions may provide cancer development and progression. This type of regulatory interactions is a key for cancer biology understanding. We aim to contribute to improving our knowledge of cancer nature!
Orphan microrna in our DB! 27 April 2018 22:14:28 by Rhizoman1
Unfortunately, we have in our DB micrornas without interactions. If it possible, we will fix these flaws!
If you find these flaws, immediately report on firstname.lastname@example.org! We immediately add appropriate interactions! We are waiting your suggestions!
Drug resistance, Apoptosis and more! 16 December 2017 17:07:26 by Rhizoman1
Next week we will annotate apoptosis interactome. It is known, that apoptosis is key process which determines efficacy of anti-cancer therapy. One of the cancer hallmark is resisting cell death. Understanding how can make rewiring in apoptotic network in cancer cells plays crucial role for enhanced cancer drug sensitivity!
E3 ubiquitin ligases and their regulatory interactions in cancer 03 December 2017 18:17:07 by Rhizoman1
In the next week we will annotate E3 ubiquitin ligase interactome! As always, it will be regulatory interactions between mIRs/TFs and E3 ubiquitin ligase mRNAs/genes. And it will also include array of E3 ligase substrates. E3 ubiquitin ligases play an essential role in the regulation of many biologic processes, especially in cancer development.
Pancreatic cancer! 01 July 2017 01:28:01 by Rhizoman1
We are begining to annotate more interactions associated with one of the deadliest form of cancer - Pancreatic Cancer!
Simple news feed (blog) about onco.io development. 26 May 2017 15:32:02 by Sasha Fokin
I make very simple blog for posting some news about onco.io development.
By now i want to know, how many different entities in our DBs. For this i made several simple snippets which show some info in main page
How the main page will look? Well, while this question remains open. On the main page, we are want to show the best possibilities onco.io. Also there should be links to key tools.
What else. Created simple pages on basic entities: pathogenetic process, disease, gene (microRNA). On the pages contains of the short information about the entities and as well as the table with the data on related interactions. The tables of all entities are interlinked.
So will we win.