ONCO.IO

ONCO.IO is an integrative resource for microrna and transcription factors analysis in cancer.

Network analysis tools Build network by filter



Database is updated every day
last update: MIR509-1=>WLS, 2018-11-11 20:41:57 by rhizoman1

ONCO.IO statistics

Total number of interactions:
15215

binding of miRNA:
5694

transcription regulation:
4373

drug interactions:
454

chemo/drugresistance:
206


metabolic reactions:
8244

TF => ncRNA reactions:
678

drug => gene/miR reactions:
454


Path. processes associations:
12945

Diseases associations:
8323

Pubmeds:
17130

Express.levels associations:
3381

Prognosis associations:
1480

Diagnosis associations:
52

Biomarker localization:
3926

Cell lines associations:
16469

Tumor stage associations:
54

Methods associations:
44426

Cell Localization:
408

number of new added interactions:
for last week:
2
(
-25
)
for last 2 weeks:
29

for last month:
52 (
-287
)

for last two month:
391

graph view


top annotators of last month:
rhizoman1:
51
(
-287
)
Вася:
1
(
+0
)

ONCO.IO is an integrated knowledge database and network analysis tool for exploring complex gene regulatory networks involved in cancer.

ONCO.IO database content is based on the manually curated annotation of experimentally verified molecular interactions described in the literature and includes microRNAs, lncRNAs, mRNAs, signaling proteins and transcription factors interactions.

Key features:



Search term and build network:


Processes

Pathogenic process (PP) - molecular, cellular or tissue malfunction determining initiation, development and outcome of disease. Full list of PP is here
Interactions (or edges) are associated with pathogenic process and can influence as positively and negatively on the process.

Processes:

Diseases

Diseases:

Genes and ncRNAs

Symbol:



News:

Immune response interactome! 06 October 2018 01:24:29 by Rhizoman1
T-cell-DC, signaling and regulatory pathways that develop immune response. Co-regulatory and repressor molecules. Receptors, signaling molecules, transcription factors as are drivers of anti-cancer immunity. Next week we will annotate immunoregulatory interactome! This is dedicated to the Nobel prize in Physiology or Medicine 2018!

Hooray! Today our database reached the milestone of 15,000 manualy curated validated links 27 September 2018 15:33:44 by Sasha Fokin



NRF2 and TRIM proteins , where is conection? 17 September 2018 00:15:16 by Rhizoman1
In addition to NRF2 interactome we will integrate TRIM proteins interactome! TRIM (Tripartite motif (TRIM) proteins) are a versatile family of ubiquitin E3 ligases involved in a multitude of cellular processes. Oxidative stress and aniviral response)

NRF2 is a key transcription factor for cancer biology 12 September 2018 15:15:14 by Rhizoman1
This week we are planning to annotate NRF2 interactome. It will include NRF2 direct transcriptional targets and upstream regulatory interactions. Now in ONCO.IO contains only 53 interactions!

We will annotate autophagy interactome! 04 August 2018 18:12:02 by Rhizoman1
Autophagy is an evolutionarily conserved catabolic process that has an essential role in cellular homeostasis. Autophagy decline with age in most tissues. And aging could be caused by declined autophagy levels.

Transcription factors interactions in specific cancer context 09 June 2018 23:08:34 by Rhizoman1
Next week we will annotate TF-->target interactions that are associated with cancer! Many of these interactions may provide cancer development and progression. This type of regulatory interactions is a key for cancer biology understanding. We aim to contribute to improving our knowledge of cancer nature!

Video on the work of ONCO.IO 15 May 2018 14:05:59 by Sasha Fokin


Blog

Last saved networks:

BNetal2018 [02 November 2018 17:34:43 by guest ]
1540837356 [31 October 2018 01:06:45 by arwa479 ]
network_1540837356 [29 October 2018 22:00:14 by guest ]
luc_tfr [29 October 2018 06:56:35 by Renatus ]
MEG3 [29 October 2018 02:32:10 by guest ]
nc [28 October 2018 19:46:29 by guest ]
mir145 mir197 [25 October 2018 15:06:57 by guest ]
mir197 145 21 downstrem [25 October 2018 14:49:36 by guest ]
NET [25 October 2018 03:20:19 by guest ]
WNT pathway proliferation test [02 October 2018 14:55:26 by guest ]
New interactions added [30 September 2018 23:28:52 by guest ]
ONCO.IO [24 September 2018 19:01:39 by guest ]
sirt1 gene regulatory network [21 September 2018 21:15:45 by guest ]
TRIM_1 [19 September 2018 02:25:26 by Rhizoman1 ]
mir21 [17 September 2018 16:01:41 by guest ]
mir21 [15 September 2018 17:32:03 by prashant20feb ]
NRF2 interactome_v1 [12 September 2018 16:38:50 by Rhizoman1 ]
Inflammasome_v1 [10 September 2018 16:59:05 by guest ]
Cytoplasmic DNA sensing_2 [10 September 2018 16:40:20 by guest ]
Cytoplasmic DNA sensing_2 [10 September 2018 01:00:49 by guest ]
Cytoplasmic DNA sensing_1 [09 September 2018 14:43:43 by guest ]
Cytoplasmic DNA sensing_1 [09 September 2018 14:38:01 by guest ]
resveratrol [31 August 2018 21:59:06 by guest ]
BMP-TGFbeta_Receptors_SMADs connection [30 August 2018 18:25:50 by guest ]
resveratrol [29 August 2018 21:41:15 by guest ]
Metastasis [29 August 2018 15:30:50 by guest ]
TGF beta [24 August 2018 18:48:59 by guest ]
network_1530257147 [29 June 2018 12:25:57 by guest ]

All saved networks




Coming soon:


Metabolites

Pubmeds

Drugs

Interactions

Mutations

Educational game