ONCO.IO

ONCO.IO is an integrative resource for microrna and transcription factors analysis in cancer.

Network analysis tools Build network by filter

Find rs ID by SNP chr/position   Find SNP chromosome and position by rs ID

Database is updated every day
last update: MIR3619=>CDK2, 2018-09-23 14:35:02 by rhizoman1

ONCO.IO statistics

Total number of interactions:
14943

binding of miRNA:
5595

transcription regulation:
4297

drug interactions:
454

chemo/drugresistance:
202


metabolic reactions:
8231

TF => ncRNA reactions:
670

drug => gene/miR reactions:
454


Path. processes associations:
12635

Diseases associations:
8167

Pubmeds:
16875

Express.levels associations:
3307

Prognosis associations:
1432

Diagnosis associations:
52

Biomarker localization:
3788

Cell lines associations:
16164

Tumor stage associations:
54

Methods associations:
43264

Cell Localization:
407

number of new added interactions:
for last week:
70
(
-27
)
for last 2 weeks:
167

for last month:
363 (
+230
)

for last two month:
496

graph view


top annotators of last month:
rhizoman1:
362
(
+229
)
Вася:
1
(
+1
)

ONCO.IO is an integrated knowledge database and network analysis tool for exploring complex gene regulatory networks involved in cancer.

ONCO.IO database content is based on the manually curated annotation of experimentally verified molecular interactions described in the literature and includes microRNAs, lncRNAs, mRNAs, signaling proteins and transcription factors interactions.

Key features:



Search term and build network:


Processes

Pathogenic process (PP) - molecular, cellular or tissue malfunction determining initiation, development and outcome of disease. Full list of PP is here
Interactions (or edges) are associated with pathogenic process and can influence as positively and negatively on the process.

Processes:

Diseases

Diseases:

Genes and ncRNAs

Symbol:



News:

NRF2 and TRIM proteins , where is conection? 17 September 2018 00:15:16 by Rhizoman1
In addition to NRF2 interactome we will integrate TRIM proteins interactome! TRIM (Tripartite motif (TRIM) proteins) are a versatile family of ubiquitin E3 ligases involved in a multitude of cellular processes. Oxidative stress and aniviral response)

NRF2 is a key transcription factor for cancer biology 12 September 2018 15:15:14 by Rhizoman1
This week we are planning to annotate NRF2 interactome. It will include NRF2 direct transcriptional targets and upstream regulatory interactions. Now in ONCO.IO contains only 53 interactions!

We will annotate autophagy interactome! 04 August 2018 18:12:02 by Rhizoman1
Autophagy is an evolutionarily conserved catabolic process that has an essential role in cellular homeostasis. Autophagy decline with age in most tissues. And aging could be caused by declined autophagy levels.

Transcription factors interactions in specific cancer context 09 June 2018 23:08:34 by Rhizoman1
Next week we will annotate TF-->target interactions that are associated with cancer! Many of these interactions may provide cancer development and progression. This type of regulatory interactions is a key for cancer biology understanding. We aim to contribute to improving our knowledge of cancer nature!

Video on the work of ONCO.IO 15 May 2018 14:05:59 by Sasha Fokin

Next week we dedicate memory Jacques Derrida who died of pancreatic cancer! 29 April 2018 00:30:52 by Rhizoman1

Pancreatic cancer is a most dangerous cancer in the world! We will annotate new interactions to improve our understanding this dangerous cancer! Please contact with us info@onco.io

Orphan microrna in our DB! 27 April 2018 22:14:28 by Rhizoman1
Unfortunately, we have in our DB micrornas without interactions. If it possible, we will fix these flaws! If you find these flaws, immediately report on info@onco.io! We immediately add appropriate interactions! We are waiting your suggestions!


Blog

Last saved networks:

sirt1 gene regulatory network [21 September 2018 21:15:45 by guest ]
TRIM_1 [19 September 2018 02:25:26 by Rhizoman1 ]
mir21 [17 September 2018 16:01:41 by guest ]
mir21 [15 September 2018 17:32:03 by prashant20feb ]
NRF2 interactome_v1 [12 September 2018 16:38:50 by Rhizoman1 ]
Inflammasome_v1 [10 September 2018 16:59:05 by guest ]
Cytoplasmic DNA sensing_2 [10 September 2018 16:40:20 by guest ]
Cytoplasmic DNA sensing_2 [10 September 2018 01:00:49 by guest ]
Cytoplasmic DNA sensing_1 [09 September 2018 14:43:43 by guest ]
Cytoplasmic DNA sensing_1 [09 September 2018 14:38:01 by guest ]
resveratrol [31 August 2018 21:59:06 by guest ]
BMP-TGFbeta_Receptors_SMADs connection [30 August 2018 18:25:50 by guest ]
resveratrol [29 August 2018 21:41:15 by guest ]
Metastasis [29 August 2018 15:30:50 by guest ]
TGF beta [24 August 2018 18:48:59 by guest ]
network_1530257147 [29 June 2018 12:25:57 by guest ]
MDALL [27 June 2018 22:52:59 by guest ]
fasdfsda [25 May 2018 12:41:57 by guest ]
31 + 94 [20 May 2018 13:13:02 by guest ]
c [17 May 2018 18:33:31 by guest ]
hsa-mirlet-7a1 hsa-mir4511 test.. [16 May 2018 15:54:48 by guest ]
from mir301a to sufu [14 May 2018 16:00:21 by guest ]
12 [06 May 2018 20:49:42 by guest ]
12 [06 May 2018 19:32:31 by guest ]
12 [06 May 2018 19:32:03 by guest ]
network_1525544327 [05 May 2018 23:18:50 by guest ]
ALL-MDR [05 May 2018 20:25:00 by guest ]
splash [04 May 2018 13:28:57 by Sasha Fokin ]

All saved networks




Coming soon:


Metabolites

Pubmeds

Drugs

Interactions

Mutations

Educational game