ONCO.IO

ONCO.IO is an integrative resource for microrna and transcription factors analysis in cancer.

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Database is updated every day

ONCO.IO statistics

Total number of interactions:
18635

binding of miRNA:
6596

transcription regulation:
5028

drug interactions:
454

chemo/drugresistance:
211


metabolic reactions:
8244

TF => ncRNA reactions:
778

drug => gene/miR reactions:
454


Path. processes associations:
15568

Diseases associations:
10152

Pubmeds:
20513

Express.levels associations:
4254

Prognosis associations:
1954

Diagnosis associations:
52

Biomarker localization:
5300

Cell lines associations:
18889

Tumor stage associations:
55

Methods associations:
53211

Cell Localization:
413

number of new added interactions:
for last week:
122
(
+38
)
for last 2 weeks:
206

for last month:
681 (
-66
)

for last two month:
1428

graph view


top annotators of last month:
rhizoman1:
681
(
-66
)

ONCO.IO is an integrated knowledge database and network analysis tool for exploring complex gene regulatory networks involved in cancer.

ONCO.IO database content is based on the manually curated annotation of experimentally verified molecular interactions described in the literature and includes microRNAs, lncRNAs, mRNAs, signaling proteins and transcription factors interactions.

Key features:



Search term and build network:


Processes

Pathogenic process (PP) - molecular, cellular or tissue malfunction determining initiation, development and outcome of disease. Full list of PP is here
Interactions (or edges) are associated with pathogenic process and can influence as positively and negatively on the process.

Processes:

Diseases

Diseases:

Genes and ncRNAs

Symbol:



Citations:

Previous version of the ONCO.IO tool (https://mirob.interactome.ru)


News:

Moscow Cancer Center Employees Threaten to Quit as Doctor Resignation Wave Hits Capital 03 October 2019 16:50:10 by Sasha Fokin
Doctors from the Research Institute of Pediatric Oncology and Hematology of the Blokhin National Medical Research Center for Oncology demanded a change of leadership. In a statement on the Doctors Alliance’s YouTube channel, they said they would quit otherwise.

Doctors complained of poor conditions for patients: lack of ventilation and mold in crowded rooms. Management, they said, instead of economic issues is engaged in "hardware struggle."

Another reason for writing applications was the dismissal of Georgy Mentkevich, the creator of the country's first bone marrow transplant department. Other specialists were forced to quit along with him.

At least 26 childrens oncologists at the Blokhin Cancer Center have threatened to quit if its recently appointed leader isnt fired, pay transparency isnt introduced and overcrowded and mold-covered wards arent replaced.


Thanks to our visitors! 26 July 2019 16:25:13 by Sasha Fokin
We thank the anonymous guest for pointing out the vulnerabilities. They are was patched, but there is still much to be done, and we are gradually completing it. While the project is running in the background.

miRs in prostate cancer: comlex regulatory connections with cancer hallmarks 18 January 2019 23:53:17 by Rhizoman1
Next week we will annotate regulatory interactions in prostate cancer. Prostate cancer (PCa) is considered the most prevalent malignancy and the second major cause of cancer-related death in males from Western countries. Androgen deprivation therapy (ADT) is the primary treatment option for male patients with advanced symptomatic PCa. Castration-resistant prostate cancer (CRPC) refers to the continuous progression of PCa following ADT. We will focus on the role of non-coding RNAs and transcription factors in prostate cancer development and progression.

Paywall: The Business of Scholarship 26 December 2018 16:17:32 by Sasha Fokin
Paywall: The Business of Scholarship is a documentary which focuses on the need for open access to research and science, questions the rationale behind the $25.2 billion a year that flows into for-profit academic publishers, examines the 35-40% profit margin associated with the top academic publisher Elsevier and looks at how that profit margin is often greater than some of the most profitable tech companies like Apple, Facebook and Google.

Paywall: The Business of Scholarship (Full Movie) CC BY 4.0 from Paywall The Movie on Vimeo.


The program of reduce the critical dependence of Russian science on foreign genetic and biological databases. 26 December 2018 16:10:04 by Sasha Fokin
"The Ministry of Education and Science proposes to allocate 220.5 billion rubles. on the development of genetic technologies in the framework of the federal scientific and technical program for the years 2019-2027. This is stated in the draft government decree on the approval of the program, published on Friday on the federal portal of draft regulations. The implementation of the program is designed to "reduce the critical dependence of Russian science on foreign genetic and biological data bases, foreign specialized software and devices, the programs passport says. In Russia, bioinformatics and genetic databases, basic reagents and software products and equipment prototypes should be created." The leading scientific organization will be the Kurchatov Institute. The ONCO.IO is made entirely by our forces and means without the help of any other structures and organizations. This is a completely independent product. For all inhabitants of the planet Earth, we provide equal access to ONCO.IO and his services.

Immune response interactome! 06 October 2018 01:24:29 by Rhizoman1
T-cell-DC, signaling and regulatory pathways that develop immune response. Co-regulatory and repressor molecules. Receptors, signaling molecules, transcription factors as are drivers of anti-cancer immunity. Next week we will annotate immunoregulatory interactome! This is dedicated to the Nobel prize in Physiology or Medicine 2018!

Hooray! Today our database reached the milestone of 15,000 manualy curated validated links 27 September 2018 15:33:44 by Sasha Fokin




Blog

Last saved networks:

qwerty1 [09 August 2020 18:59:31 by guest ]
lncRNA_miR_mRNA_ex_module [09 August 2020 18:01:44 by guest ]
mir150 and 186 interaction [07 August 2020 16:40:59 by guest ]
123456 [05 August 2020 02:45:26 by guest ]
EMT_cancer_v1 [03 August 2020 14:44:22 by guest ]
[25 July 2020 15:10:52 by guest ]
EMT_cancer_v1 [25 July 2020 14:32:35 by guest ]
EMT_cancer_v1 [25 July 2020 14:20:08 by guest ]
The molecular circadian clock [23 July 2020 15:00:31 by guest ]
The molecular circadian clock [23 July 2020 13:49:08 by guest ]
mTOR_signaling_v1 [21 July 2020 20:55:19 by guest ]
mTOR_signaling_v1 [21 July 2020 14:35:44 by guest ]
mTOR_signaling_v1 [21 July 2020 13:37:18 by guest ]
mTOR_signaling_v1 [21 July 2020 13:10:23 by guest ]
Regulation of cholesterol homeostasis [20 July 2020 10:53:06 by guest ]
Regulation of cholesterol homeostasis [20 July 2020 10:44:53 by guest ]
Regulation of cholesterol homeostasis [19 July 2020 15:58:48 by guest ]
Regulation of cholesterol homeostasis [19 July 2020 15:06:08 by guest ]
Regulation of cholesterol homeostasis [19 July 2020 15:01:50 by guest ]
Regulation of cholesterol homeostasis [19 July 2020 14:42:03 by guest ]
Regulation of cholesterol homeostasis [19 July 2020 13:55:54 by guest ]
Autophagy_v1 [18 July 2020 23:24:31 by guest ]
Autophagy_v1 [18 July 2020 21:51:41 by guest ]
Autophagy_v1 [18 July 2020 21:49:26 by guest ]
Autophagy_v1 [18 July 2020 21:22:15 by guest ]
Hippo_v2 [17 July 2020 01:49:55 by guest ]
Hippo_v2 [17 July 2020 01:48:43 by guest ]
Hippo_v2 [17 July 2020 00:48:15 by guest ]
Hippo_v2 [16 July 2020 14:50:42 by guest ]
Hippo_v2 [16 July 2020 14:40:23 by guest ]
Hippo_v2 [16 July 2020 14:10:24 by guest ]
Hippo_pathway [16 July 2020 00:40:28 by guest ]
IFN_antiviral_response_v1 [14 July 2020 16:52:48 by guest ]
IFN_antiviral_response_v1 [14 July 2020 16:51:08 by guest ]
IFN_antiviral_response_v1 [14 July 2020 16:47:12 by guest ]
IFN_antiviral_response_v1 [14 July 2020 14:30:10 by guest ]
Hippo_pathway [14 July 2020 10:58:43 by guest ]
Hippo_pathway [14 July 2020 10:31:03 by guest ]
Complement system_v1 [14 July 2020 10:22:38 by guest ]
drugs view2b [13 July 2020 21:42:28 by guest ]

All saved networks




Coming soon:


Metabolites

Pubmeds

Drugs

Interactions

Mutations

Educational game