LINC00339 has been shown to mask the expression of miR-497-5p. Downstream to LINC00339/ miR-497-5p, the next player that has been identified is IGF1R (Insulin-like growth factor-I). IGF1R has binding sites of miR-497-5p, hence LINC00339 may function via adsorbing miR-497-5p and then increasing the expression of IGF1R to exert its cancer-promoting effect (32871244)