LncRNA LINC00665 is overexpressed in lung adenocarcinoma (LAD) tissues and can promote cell proliferation and tumorigenesis. It can directly bind to EZH2，which is a crucial enzyme of PRC2, and activate the PI3K/AKT pathway. Silencing LINC00665 can impair lung cancer cell proliferation and promote apoptosis, thereby inhibiting resistance to gefitinib-resistant cells (32871184)