both
PTEN and PTENP1 are directly regulated by miR-21, and their expression is
inversely correlated with miR-21 expression. PTENP1 expression relieves the
suppression of PTEN expression by miR-21, indicating PTENP1 is a competing
endogenous RNA, competing with the binding of miR-21 with PTEN, thus relieving
the suppression of PTEN by miR-21 in ccRCC. (25249556)