LINC00460 (non-coding RNA) == binding ==> MIR149 (5p microRNA)

LncRNA LINC00460 acts as a ceRNA of miR-149-5p to promote IL-6 production. IL-6 induces EMT phenotype by activating the JAK/STAT3 and AKT signaling pathways, which are associated with the resistance of NSCLC with T790M mutation to Afatinib. (32871184)

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