MIR21 (5p microRNA) == microRNA binding ==> PTENP1 (non-coding RNA)

both PTEN and PTENP1 are directly regulated by miR-21, and their expression is inversely correlated with miR-21 expression. PTENP1 expression relieves the suppression of PTEN expression by miR-21, indicating PTENP1 is a competing endogenous RNA, competing with the binding of miR-21 with PTEN, thus relieving the suppression of PTEN by miR-21 in ccRCC. (25249556)